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• Published on: 2005-08-30
• Binding: Hardcover

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Designing Clinical Research has been�extensively revised and continues to set the standard as a practical guide for doctors, nurses, pharmacists, and other health professionals involved in all forms of clinical, translational, and public health research. It presents advanced epidemiologic concepts in a reader-friendly way, and suggests common sense approaches to the challenging judgments involved in designing, funding, and implementing.

New to this edition:

• Expanded and updated content in every chapter, with new material on: • non-inferiority trials for comparative effectiveness research • incidence-density case-control studies • confounding and effect modification • diagnostic test studies to inform prediction rules • ethical aspects of whole genome sequencing • automated data management approaches • new NIH grant-writing requirements
• Color format, and Electronic access, powered by Inkling™ as a free companion to the text • viewable through your browser or as a download to tablet or smartphone • the complete text with optimized navigation • note-sharing, highlighting and bookmarking capability • cross-linking of references and content • rapid search options linked to the new glossary

• Sales Rank: #17409 in Books
• Published on: 2013-07-02
• Original language: English
• Number of items: 1
• Dimensions: 10.00" h x 7.00" w x .50" l, 1.39 pounds
• Binding: Paperback
• 378 pages

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10 of 11 people found the following review helpful.
Great Text on Trials
By Dr. Terrence McGarty
Clinical Trials have evolved over the past few decades in multiple dimensions. There are legal, regulatory, statistical, procedural, and clinical dimensions which tend to structure them in ways which were not prevalent to anyone who entered medicine decades earlier. The book by Hulley et al, Designing Clinical Research, is a wonderful overview of most of these dimensions. It brings the reader up to date with many of the key factors which have become part of Trials and give an excellent amount of depth so that the book stands on its own.

The book is divided into three major sections; (i) Basics including sampling, trial hypotheses testing and statistical analyses as well and general trial types. (ii) Designs which examines the various types of trials from randomized case control, cross-sectional, and other such classic trial methodologies, (iii) Implementation, including the ethical issues and data management.

The Basics provides a reasonable overview of the randomization, sizing, and the establishment of the statistical plan for a Trial. The approach is classic with the null hypothesis approach and the metrics necessary for properly sizing a successful Trial. The presentation is in a summary nature and the reader is either expected to be familiar with the development of the mathematics or just to use the Tabular approaches as presented. There are excellent discussions on various approaches such as continuous versus dichotomous and the material is useful even for those well experienced in the area.

The Designing sections go over the details associated with various Trial approaches and discuss the implementation, and the advantages and disadvantages. Again, even for someone already familiar with the material the authors provide added insight well worth the reading. Again when discussing such elements as likelihood designs and Receiver Operating Characteristics the material is of a summary nature, adequate for both understanding and application but not of any material depth. Yet that was never the objective of the book.

Finally in implementation the authors present an excellent discussion of the Ethical Issues that are frequently found in many Trials. There are other elements here as well but the Ethical discussions have become more prevalent to current day Trials.

The challenge that this and other works on Trials will be facing are the Trial involving genome based approaches. For example in MDS and the use of demethylating therapeutics such as azacytidine and others one may ask the ethical question; if this is demethylating and methylation is both the cause while also being a control in other cells, how long should one wait to see long term effects? In cases such as the BRAF inhibitors in melanoma, what import is the extension of life if the costs are so great? Also how aggressively should one approach multiple drug therapies? Finally, as we see more genetically specific drugs on a patient by patient basis, can Trials like those discussed herein still be considered a gold standard and if not what then would take their place. Therapeutics targeted at a specific genome type will be difficult to analyze as we have with large Trials discussed in the book.

Overall the book is a superb overview of Trials and is worth a read by finishing Med Students, Resident, and even those experienced in Trials. It is well written, logically laid out, considers almost all the key questions, and presents information adequate for most.

1 of 1 people found the following review helpful.
A "must have" clinical research books.
By T. E. Underwood
Great for MDs or PhDs wanting to refresh their knowledge on how to design the strongest research methodology they can. Clearly written book discussing different study designs and their pros and cause when trying to establish a causal association between an exposure and a disease event (or intervention and reduced disease event). This book focuses on clinical research, but is often used in public health courses that deal with general community research as well.

The fact that it's used often as a textbook is reflected in its very high price point.

1 of 1 people found the following review helpful.
Intellectually-Stimulating Genetic Research Textbook
By E. Charles
I read this book during my clinical research studies. I continue reading it after graduation. I always look forward to the re-introduction of the material. At the same time, I learn something new from the book. I would highly recommend it to clinical research students. It is an excellent required and recommended textbook.

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• Sales Rank: #11020469 in Books
• Published on: 1998-02-28
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(Play It Like It Is). With their intense chemistry and electrifying live shows, doom metal group the Sword was known as "Austin's most dangerous band." Success at SXSW broadened their fan base, and lead to this hit first CD. Our songbook contains note-for-note, artist-approved transcriptions of all nine songs: Barael's Blade * Celestial Crown * Ebethron * Freya * The Horned Goddess * Iron Swan * Lament for the Aurochs * March of the Lor * and Winter's Wolves, plus a band bio.

• Sales Rank: #1334014 in Books
• Published on: 2010-12-01
• Original language: English
• Number of items: 1
• Dimensions: 12.00" h x .22" w x 9.00" l, .60 pounds
• Binding: Paperback
• 76 pages

Most helpful customer reviews

1 of 1 people found the following review helpful.
A very precise guitar tab book
By Jeff Kormos
*Note - these songs are all in C Standard tuning (C F Bb Eb G C), so make sure you have the proper string gauge!

This is a very precise guitar tab book and the layout makes it very easy to learn these songs. I was able to learn the songs from this book very quickly and there is also notation along with the tab. The book arrived in pristine condition and had no bends or creases. I look forward to purchasing more tab books from this line.

If you're a fan of The Sword and this album, I highly recommend it pick it up!

0 of 0 people found the following review helpful.
It's great to see a songbook for The Sword
By JerryM
I am glad that a songbook exists for this album which I think is on of the best metal records ever. I'd like to see more songbooks for somewhat lesser known bands than say Metallica or Slayer.

0 of 0 people found the following review helpful.
Fantastic transcription
By Paruer
Fantastic transcription. The author very faithfully follows the music. I could find no errors for even this pretty complex music.

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[I601.Ebook] Ebook Designing Effective Logos: Learn by Video, by Maggie Macnab

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Designing Effective Logos: Learn by Video, by Maggie Macnab

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The DNA of a strong business identity is its logo, making effective logos key to the success and longevity of any business. In this six-hour video, educator, author, and award-winning logo designer Maggie Macnab explores how to create powerful logos that are meaningful, effective, and substantial enough to scale over time and beyond trend.

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Macnab pulls from her 30 years of experience as a designer and educator to reveal the secrets to making your logos memorable, aesthetic, and immediate through universal principles and shapes. She explains the basic principles of successful logo designs (balance and proportion, symmetry, the 5 Gestalts, etc.) and the importance of visual storytelling as you conceive your logo designs. She also offers practical business approaches to sourcing clients, strategies for designing what you’re drawn to, advice on how to draft a successful proposal to land the job, and guidance on how to legally protect your work–the essentials of logo business–along with the fun stuff of finding inspiration, exploring software tools, and developing your creative skills as the basis of logos that truly work.

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In this video, you will learn about:

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• Different types of logos, from symbolic to literal

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• The business of logo design: contracts and legal considerations

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• Logo design principles such as gestalt, negative/positive space, visual storytelling, scaling, and economy

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• Secondary logo design considerations: color, typography, and technique

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• Creating identity guidelines to maintain the integrity of the brand and to support your client’s future brand

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This video course comes with review mini-tests and exercises to help gauge your progress and understanding of the material. The video is wrapped in a unique interface that allows you to jump to any topic and also bookmark individual sections for later review. The popular “Watch and Work” mode shrinks the video into a small window to allow you to work alongside the instructor, practicing what you learn and reinforcing freshly gained knowledge.

System Requirements
Mac OS X 10.6, Microsoft Windows XP, or higher
GHz processor or higher
2 GB RAM or higher
1 GB Free HD Space (does not include lesson files)

Please note that this DVD can be viewed only on a computer. It will not work in DVD-Video player software or a DVD set-top player.

• Sales Rank: #4871396 in Books
• Brand: Pearson Educational Group
• Published on: 2014-10-20
• Original language: English
• Subtitled in: English
• Number of items: 1
• Dimensions: 7.50" h x .60" w x 5.30" l, .15 pounds
• Binding: DVD-ROM

About the Author

Maggie Macnab has been recognized as an innovative visual communicator for over three decades. She teaches design theory at the University of New Mexico, The Institute of American Indian Arts, Santa Fe Community College, and Santa Fe University of Art and Design, and is past president of the Communication Artists of New Mexico. Macnab speaks at conferences (she's a two-time speaker for TEDx), guest lectures and gives workshops for schools and groups, and consults on developing cohesively strategic and creative identities with clients. Macnab is the author of Design by Nature (Peachpit Press, 2012), which was the recipient of the 2012 New Mexico-Arizona Book Award for Non-Fiction. She lives in Santa Fe, New Mexico.

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0 of 0 people found the following review helpful.
This video gave me just the tools I needed!
By I Gibbs
This is an absolutely must have for all logo designers aspiring to take their craft to the next level and to those like me, who needed insight for my business logo.

I was thrilled at the level of talent, attention to detail, and the energy she placed into her work. Maggie has a way of explaining so many elements of principle to its simplest form. Her insight into logos, identity, and branding were of pure passion for what she does.

My personal favorite sections were understanding the concepts of shapes and the many logo types.

Above all, I am so pleased this DVD exceeded my expectations. Designing Effective Logos is the best!

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[F669.Ebook] Download Ebook Engineering Analysis of Vehicular Accidents, by Randall K. Noon

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Engineering Analysis of Vehicular Accidents, by Randall K. Noon

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Accident analysis is not like a classroom problem where the equations are selected and solved, and the matter is considered closed. In this line of forensics, engineering skill must be combined with skillful practice for the successful presentation of evidence to a jury.

In this book, the author demonstrates the application of engineering skills, methods, and judgment for analyzing vehicular accidents. A definition of vehicular accident reconstruction and its role in the legal system is provided. General accident statistics are cited, and some general strategies for accident reconstruction are given, along with many examples and case studies. The author includes novel and unusual treatment of the momentum method and coefficient of restitution (which is not yet widespread in accident analysis) and shows how to select the best methods of analysis in a given accident reconstruction.

• Sales Rank: #1155244 in Books
• Brand: CRC Press
• Published on: 1994-02-23
• Ingredients: Example Ingredients
• Original language: English
• Number of items: 1
• Dimensions: 9.53" h x .88" w x 6.40" l, 1.10 pounds
• Binding: Hardcover
• 250 pages

Features

• Used Book in Good Condition

Most helpful customer reviews

17 of 19 people found the following review helpful.
Excellent - good mix of mathematics and real experience.
By Max Bez
Excellent description of the mathematical models used to reconstruct and understand (primarily)car accidents. Includes worked out examples and a careful and common sense derivation of the equations used. The only slight drawback is that the author did not use (or have access to) typesetting that allows for showing math equations in the traditional format, ie the square root of 2 times gravity-constat times distance time coeff of friction is would be written as s=(2*g*f*d)1/2 power. It's very easy to get past this and the prose/descriptions/examples are very good.

0 of 0 people found the following review helpful.
Five Stars
By Jose A. Araya
Excellent book with useful explanations.

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[C551.Ebook] Free PDF Supercapitalism: The Transformation of Business, Democracy, and Everyday Life, by Robert B. Reich

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From one of America's foremost economic and political thinkers comes a vital analysis of our new hypercompetitive and turbo-charged global economy and the effect it is having on American democracy. With his customary wit and insight, Reich shows how widening inequality of income and wealth, heightened job insecurity, and corporate corruption are merely the logical results of a system in which politicians are more beholden to the influence of business lobbyists than to the voters who elected them. Powerful and thought-provoking, Supercapitalism argues that a clear separation of politics and capitalism will foster an enviroment in which both business and government thrive, by putting capitalism in the service of democracy, and not the other way around.

• Sales Rank: #360049 in Books
• Brand: Reich, Robert B.
• Published on: 2008-09-09
• Released on: 2008-09-09
• Original language: English
• Number of items: 1
• Dimensions: 8.00" h x .61" w x 5.13" l, .48 pounds
• Binding: Paperback
• 288 pages

From Publishers Weekly
In this compelling and important analysis of the triumph of capitalism and the decline of democracy, former labor secretary Reich urges us to rebalance the roles of business and government. Power, he writes, has shifted away from us in our capacities as citizens and toward us as consumers and investors. While praising the spread of global capitalism, he laments that supercapitalism has brought with it alienation from politics and community. The solution: to separate capitalism from democracy, and guard the border between them. Plainspoken and forceful, if somewhat repetitious, the book urges new and strengthened laws and regulations to restore authority to the citizens in us. Reich's proposals are anything but knee-jerk liberal: he calls for abolishing the corporate income tax and labels the corporate social responsibility movement distracting and even counterproductive. As in 2004's Reason, Reich exhibits perhaps too much confidence in Americans' ability to think and act in their own best interests. But he refuses to shift blame for corporations' dominance to the usual suspects, instead pointing a finger at consumers like you and me who want better deals, and from investors like us who want better returns, he writes. Provocatively argued, this book could help begin a necessary national conversation. (Sept. 6)
Copyright � Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From Booklist
Reich, professor of public policy and former secretary of labor, argues that as the U.S. has grown stronger as a capitalist economy, it has grown weaker as a democratic nation. Reich begins by looking at the political and economic history that has contributed to the particular brand of capitalism and democracy practiced in the U.S. and how democracy is threatened as more and more Americans are engrossed in their roles as consumers and investors and less so as citizens. He recalls the "almost Golden Age" of the 1950s, a period of stability as large corporations, big labor, and government managed the interests of consumers, workers, management, and investors for the "common good." The spread of capitalism to a global level hasn't corresponded with a spread of democracy throughout the world and has led to some negative social consequences at home, including widening inequalities and a shrinking social safety net. Reich asserts that although Americans dislike what lower wages are doing to us as a nation, when weighed against lower prices or higher return on investments, we vacillate or look the other way. Reich uses tables and charts and plain speech to describe how the economy has grown so efficient and effective that the human equation is lost and how the democracy has become less and less responsive to common values. As citizens, we need to "make our purchases and investments a social choice as well as a personal one," Reich maintains. Bush, Vanessa

Review
"Reich documents in lurid detail the explosive growth of coporate lobbying expenditures and campaign contributions since the 1970s. . . . Supercapitalism is a grand debunking of the conventional wisdom in the style of John Kenneth Galbraith." —The New York Times"Reich turns the standard liberal critique of corporations on its head."—Forbes"A thoughtful and heartfelt critique of the ruthless, hell-bent-for-profit brand of capitalism that has been in vogue under Democrats and Republicans alike since roughly the end of the cold war."—Portfolio"Supercapitalism describes important and sweeping economic changes. . . . Reich has a talent for making economics accessible and sometimes even fun."—The Los Angeles Times

Most helpful customer reviews

75 of 79 people found the following review helpful.
A thoughtful, realistic view of our present situation
By Marshall Goldsmith
My friend Joanie's father was uneducated and had a very poor work ethic. Yet he worked for a union for 30 years, retired in his 50's and collected health care and pension benefits for 30 more years. His wife did not work, they lived in a nice home in the suburbs and he put three kids through college.
He was fortunate enough to have been born in the right place at the right time (as well as being of the preferred race and sex).
His grandson, Jared, Joanie's son, is 25, has three years of college education, works very hard (about 60 hours per week), lives with his mother and will probably never be able to afford the home and lifestyle experienced by his grandfather.
While the US GDP has grown rapidly, the benefits of the process are not readily visible to Jared - or millions of other young people like him.
Supercapitalism does an excellent job of explaining what has happened to the US economy - and why Jared is having a harder time than his grandfather.
While the term 'fair and balanced' is overused by parts of the media, this book is actually 'fair and balanced'!
Rather than bashing corporations - and corporate executives - Reich points out that they should be expected to do what they do - provide the best products at the lowest prices for consumers and provide a competitive return for stockholders.
He also says that we, as citizens, should become more actively involved in making decisions that are in the best interest of our country.
Reich discusses a major roadblock for citizens to overcome when he notes, "But the largest impediment to reform is one brazen fact: Many politicians and lobbyists want to continue to extort money from the private sector. That's how politicians keep their hold on power and lobbyists keep their hold on money."
Supercapitalism presents a clear analysis of why we are where we are - and a call to action for citizens to become more involved in promoting the common good.

79 of 88 people found the following review helpful.
Whether or not you agree with Reich SUPERCAPITALISM opens up a dialogue on economics and social responsibility
By Wayne Klein
Robert Reich makes a compelling argument that supercapitalism has robbed democracy of much of its power. Supercapitalism by the definition presented in the book is simple--the consumer is king and prices ALWAYS go down. What Reich looks at is the cost of low prices to companies, society, the individual and its impact on the workings of democracy. So how is democracy compromised? Reich also points out that the rise of different lobbying groups, the cost of politics and globalization as contributing to this process. This isn't a surprise. It has just become more pronounced with time.

It's not due to some large conspiracy or any hidden political agenda as much as it is driven by consumption. Ultimately Reich argues that it robs the common citizen of any control over democracy. It's not surprising that this is a highly charged issue because the economics of what benefits society (or "the common good" as Reich calls it)often gets tangled up in the web of politics. Reich also points out that the cost of supercompetitiveness, constantly falling prices is a loss to the economic and social health of America. Reich points out that everyone wants to get the lowest price possible but he also suggests that we must balance that with our desire to have decent wages and benefits. He also points out that the move towards regulation was initiated by government and that corporations went along because it kept out competition and guaranteed a top and bottom for prices allowing companies to get a profit without fear of cutting prices so low that it would put them out of business.

I should point out that this is an oversimplification of Reich's points but it does capture some of the concepts. He also makes some suggestions that would help keep the free market afloat without undermining democracy and allowing consumers to still benefit from competitive pricing. Since this is economics we are discussing politics is mixed in and might color whether or not you agree with his points.

Reich's style is breezy for a book that looks at economics, democracy and the erosion of wages, benefits. Reich comes across as fair balanced and thoughtful even as he sells his take on what is undermining American society. Ultimately it's a worthwhile book to read simply because it opens up dialogue on the social cost of constantly lowering prices and how it impacts those who live next door to us.

9 of 9 people found the following review helpful.
The Cliff's Notes version
By CrunchyCookie
This book rocks, but given the multitude of reviews out there already (and that I like it for the same reasons everyone else does), I thought I'd make my contribution by giving a quick summation of the contents.

Basically, the whole book is about how this country is supposed to run on the dual ideals of capitalism and democracy, but lately, the forces of capitalism have been crushing the democracy part. Reich says it's our own damn fault: our greed for $$$$$$$$$$ and Return On Investment have driven the vast majority of our actions as consumers and investors, causing the very social ills we complain about (job insecurity, massive wage inequality, depraved garbage on TV, etc.)

He makes the point that it's illogical to scapegoat Wal-Mart and friends no matter how big they are, since they're basically playing by the rules and doing exactly what we demand of them. In fact, when a company shows the slightest sign of generosity (i.e. when Costco's CEO lets its employees pay only 8% of their healthcare costs instead of the usual 25%) it instantly gets slammed; any CEO that isn't doing everything to "maximize shareholder value" usually gets the boot. Investors don't care about much else besides the bottom line (and even when they do, their purchasing patterns don't reflect it), which is why they're willing to pay whatever it takes to get the most profit-generating CEO (and then later, of course, everyone gripes about massively overinflated CEO salaries).

Basically, we're all hypocrites and morons, but Reich reminds us that it's not entirely our fault, because the system makes it a lot easier to express your voice via capitalism than via democracy. For example, you can choose where to shop, what companies to invest in, and what CEOs you want in charge, but if you try to speak your mind about something like how the media is debasing society, well, there's no real specific constructive outlet for it, and chances are you won't be heard above the din.

I guess this stuff should be obvious, but I never really thought about it before, and anyway it's rad how he analyzes everything so deeply, fairly, and realistically -- lessons yet to be learned by sycophants like Michael Moore.

As a sidenote, I also picked up on a few interesting nuggets of truth, like:
- Costco's customers have more than 2X the income of Wal-Mart customers. I also heard that Costco's CEO only makes a six-figure income (unheard of for CEOs) and the company pays people about $17/hour vs. Wal-Mart's $10. Sounds like a really thoughtful company.
- Reich thinks it's silly that the 80s was known as the decade of greed, as if that mentality wasn't there before. Plus, a lot of the seeds and statistics of this gaping inequality started in the 70s. Ack, I forgot which ones.

Anyway, definitely recommended.

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